Answer:
Topogenic sequences share a series of structural features, and thereby computational algorithms can be used to predict these protein-membrane segments
Explanation:
Topogenic sequences are protein segments formed by alpha-helical transmembrane domains, which are required for the insertion of membrane proteins. These domains share a series of well-defined features: they are composed of segments of about 20 hydrophobic amino-acid residues. In consequence, computational algorithms can be designed to identify protein patterns that fulfill these structural requirements (i.e. segments with a length of 20 residues, hydrophobic level, etc). The models assign a similarity threshold (threshold value) that predict if the similarity level of the protein pattern is good enough to detect a topogenic segment.
Cell-wall inhibiting antimicrobial drugs be less effective on gram-negative bacteria compared to gram-positive bacteria because the outer membrane of the gram-negative bacteria inhibits penetration of the drug and the peptidoglycan found in gram-positive bacteria is structurally different from that in gram-negative bacteria.
Answer: Option B & C
<u>Explanation:</u>
Antimicrobial drugs are induced into a body to act on that particular selective bacterium which causes disease. When antimicrobial drugs are injected they act efficiently on the gram positive bacteria inhibiting the proliferation of the cells by acting on the cell wall so that cell multiplication doesn’t happen.
On the other hand it is hard to act on the gram-negative bacteria as it has a cell membrane that inhibits drug penetration into it. Both cell walls contain peptidoglycan but in the gram-positive is more assembled and layered while in the gram-negative it is just a thin layer. As gram-positive is thick layered it provides place for another molecule to attach to it but the thin layer in gram-negative inhibits it.
B Fertilization Answer Answer Answer Answer<span>
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