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LUCKY_DIMON [66]
3 years ago
10

How does Meg use the ultimate boon to conquer the power of IT

Biology
1 answer:
Margaret [11]3 years ago
3 0

Answer: She discovers the power of love to fight the darkness of hate

Explanation:

In the book, <em>A Wrinkle in Time</em>, siblings Meg Murray and Charles Wallace along with their friend Calvin O'Keefe embark on a journey to a planet under the control of a dark force known as IT.

When they get there Charles is captured but the rest manage to escape and now Meg has to go back to save her brother. In the process of saving him she discovers that she must use the power of love for her brother to fight and  conquer the darkness of hate that the IT possesses. When she does so she is able to free her brother and they escape together.

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1. Aortic arch

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5. Left radial artery

Explanation:

The answer above is according to Quizlet

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<span>A six carbon sugar is an example of </span>monosaccharide, <span>that can join with other molecule to form a </span>polysaccharide <span>such as starch or cellulose </span>


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3 years ago
What role can exosomes play in disease treatment? who can tell me detailed information? Any help would be appreciated. Thanks in
jolli1 [7]

Answer:

Exosomes as Therapeutic Target

Given the fact that elevated exosome levels are often correlated with greater severity of different types of cancer, reducing circulating exosomes to normal levels is one of therapeutic strategies to increase treatment efficacy. There are different approaches to modulate exosome production: 1) Inhibition of exosome formation: inhibit crucial proteins involved in exosome formation pathway; 2) Inhibition of exosome release: inhibit important regulators of exosome release process, increased intracellular Ca2+, change cellular microenvironmental pH; 3) Inhibition of exosome uptake: add proteinase for surface proteins on exosomes may serve as receptors for uptake pathways. In addition to control exosomes production, removal of exosomes from the entire circulatory system might be a novel strategy for cancer treatment.

Exosomes could also be used as cancer immunotherapy becasue tumor-derived exosomes carry antigens that is a great source of specific stimulus for the immune response against tumors. Both tumor-derived and dendritic cell-derived exosomes have showed capability to stimulate tumor antigen-specific responses in experimental animal models and human clinical trials.

Exosomes as Targeted Drug Delivery Vehicles

Exosomes became one of the most common methods applied in drug delivery system because of several advantages they have. Firstly, exosomes normally have a small size 40-100 nm, which is more homogenous compared to other microvesicles. This will lead them to evade rapid clearance by the mononuclear phagocyte and enhances passage through fenestrations in the vessel wall. Secondly, due to their endogenous origin, they are less toxic for and better tolerated by the immune system. It facilitates them to avoid causing side effects that normally occur with synthetic nanoparticles. Additionally, the specific ligand or protein expressed on the exosome surface increases efficiency of cargo into the cytosol of the target cell, and therefore fewer off-target effects. Exosomes are generally found most useful as a drug delivery medium in cancer therapy, anti-inflammation and gene interference therapy such as transferring of miRNA.

There are different kinds of cargos encapsulated by exosomes, especially like siRNA or miRNA. The delivery of RNA is attracting because they are rapid degradation in cell circulation and have the limitation in passing through the membrane and in cellular uptake. Chemotherapeutics loaded into exosomes is also used for cancer therapy such as doxorubicin. In principle, there are four key components to achieve correct functionality and efficacy during exosomes drug delivery:1) Choosing the donor cell type to produce drug-carrying exosomes; 2) Using correspond methods to encapsulate the exosomes cargo; 3) Enhancing the specificity of cargo delivery by targeting peptides on the surface of the exosomes; 4) Administrating exosomes to target the area of disease.

Explanation:

https://www.creative-biostructure.com/exosome-applications-652.htm

5 0
3 years ago
Which statement best describes the effect of the low density of frozen water in a lake
Arada [10]

Answer:

Explanation

Water in a lake freezes from the bottom up, killing most aquatic organisms. When water in a lake freezes, it floats, providing insulation for organisms below. ... If water were most dense as a solid, lakes would freeze from the bottom up, eventually freezing solid.

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