A :-) Sickle cell disease occurs more often among people from parts of the world where malaria is or was common. It is believed that people who carry the sickle cell trait are less likely to have severe forms of malaria.
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Troposphere should be the answer
Making rough estimate of physical quantities is useful because it allow us to have an idea of how big or small a quantity is, it gives us the near result of the real quantity a matter contains. The approximate quantity obtained will give us information about the size of the quantity.