Sickle cell disease provides an example for which principle of molecular genetics?

Biology

1 answer:

Alisiya [41]3 years ago

7 0

Answer:

The correct answer is D a change to one amino acid in a protein may cause a significant change in the phenotype.

Explanation:

Sickle cell anemia is caused by the replacement of 6th amino acid in the beta chain of hemoglobin that is glutamic acid by valine.

glutamic acid is a hydrophilic amino acid that is being replaced by a hydrophobic amino acid known as valine.

As a result the red blood cells appear as insoluble aggregates which which ultimately result in the sickling of Red blood cells.That"s why this disease is named as sickle cell anemia.

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