Definitely harmful, the Catholic Church is actually what really caused the problems because the interaction between the two made diseases spread, and fights begin when Native Americans didn't want to change
The answer would be:
Thermohaline circulation
It has an impact on climate because when the currents continue to flow through the ocean, cold water is likely to be denser and this density has salt in it. This is important for the ocean, for it bring nutrient water in the surface and to freshened the polar region<span>’s of earth associated with global warming.</span>
There were smarter, more qualified people working for the government which lead to a stable government.
Laws would vary from one State to the other, which would make it difficult to adhere to if you're not from that State. Also, politics would play into effect. I'd like to use the American Civil War as an example; some states were for Slavery, meanwhile others sided on the abolishment side. That could come into play here, and that could be extremely dangerous.