Bloom syndrome (BS) is a rare autosomal recessive disorder characterized by growth deficiency, immunodeficiency, genomic instability, and the early development of cancers of many types. BLM, the protein encoded by BLM, the gene mutated in BS, is localized in nuclear foci and absent from BS cells. BLM encodes a DNA helicase, and proteins from three missense alleles lack displacement activity. BLM transfected into BS cells reduces the frequency of sister chromatid exchanges and restores BLM in the nucleus. Missense alleles fail to reduce the sister chromatid exchanges in transfected BS cells or restore the normal nuclear pattern. BLM complements a phenotype of a Saccharomyces cerevisiae sgs1 top3 strain, and the missense alleles do not. This work demonstrates the importance of the enzymatic activity of BLM for its function and nuclear localization pattern.
<u><em>What DNA sequence were the researchers trying to detect? </em></u>
<u><em>Are you referring to the choices below?</em></u>
Answer:
DNA and fingerprint technology is said to be very accurate as it uses chemicals to separate strands of your own unique DNA to reveal the unique parts of your genome. which is your genetic make-up
This technology emerged in 1984 and invented by Professor Sir Alec Jeffreys who realized that you could detect variations in human DNA, in the form of these mini-satellites to produce a pattern unique to an individual
Human error still plays a role in terms of lab staff who make errors in conducting the DNA analysis, interpreting it or reporting the results of the analysis sometimes it occurs in entering the resulting DNA profile into a DNA database system which may result from a failure to comply a procedure, misjudgement, or some other mistake. There are protocols and precautions which can be introduced to minimise the opportunity for error during analysis or interpretation, however, the potential for human error cannot be fully eliminated.
The answer is to do what you must my friend, goodluck!!
#1
Inner stem cell mass
#2
Harvested Unspecialized Embryonic Stem Cells
