<span>Lafora disease is the most severe teenage-onset progressive epilepsy, a unique form of glycogenosis with perikaryal accumulation of an abnormal form of glycogen, and a neurodegenerative disorder exhibiting an unusual generalized organellar disintegration. The disease is caused by mutations of the EPM2A gene, which encodes two isoforms of the laforin protein tyrosine phosphatase, having alternate carboxyl termini, one localized in the cytoplasm (endoplasmic reticulum) and the other in the nucleus. To date, all documented disease mutations, including the knockout mouse model deletion, have been in the segment of the protein common to both isoforms. It is therefore not known whether dysfunction of the cytoplasmic, nuclear, or both isoforms leads to the disease. In the present work, we identify six novel mutations, one of which, c.950insT (Q319fs), is the first mutation specific to the cytoplasmic laforin isoform, implicating this isoform in disease pathogenesis. To confirm this mutation's deleterious effect on laforin, we studied the resultant protein's subcellular localization and function and show a drastic reduction in its phosphatase activity, despite maintenance of its location at the endoplasmic reticulum.
I got my information from </span>https://www.ncbi.nlm.nih.gov/pubmed/14722920
Answer:
The humble sunflower appears not quite of this earth. Its yellow crowned head sits atop its stalk like a green broomstick. Its seeds, arranged in a logarithmic spiral, are produced by tiny flowers called disc florets that emerge from the center of its head and radiate outward. But aside from being a biological marvel, the sunflower is also often in the scientific spotlight.
From understanding how new plant species emerge to studying “solar tracking,” which is how the flowers align themselves with the sun’s position in the sky, sunflowers are a darling in the field of science. However, researchers can only get so far in understanding a plant without detailed genetic knowledge. And after close to a decade, it has finally unfurled itself.An international consortium of 59 researchers who set their sights on the laborious task of sequencing and assembling the sunflower’s genome published their results in a 2017 study in Nature. This achievement will provide a genetic basis for understanding how the sunflower responds and adapts to different environments. “We are on the cusp of understanding sunflower adaptability,” says Loren Rieseberg, a leading sunflower expert at the University of British Columbia and a supervisor of this study.
With its genome assembled, scientists are hopeful for the next phase of the sunflower’s scientific career: as a “model crop” for studying climate adaptability in plants. This task is more complex and urgent now than ever. Climate change, according to a paper in the Annals of Botany, “will influence all aspects of plant biology over the coming decades,” posing a threat to crops and wild plants alike.
Answer:
the population can increase rapidly when the conditions are favourable
only one parent is needed
it is more time and energy efficient as you don't need a mate
it is faster than sexual reproduction
Monosaccharides are made of carbon,hydrogen, and oxygen atoms
Answer:
decomposer
Explanation:
producer-consumer-decomposer
