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The chemical receptors of cells have been defined as molecular structures to which other molecules considered as chemical messengers (neurotransmitters, hormones and other neuroactive molecules) specifically bind.
Chemical receptors can be located on the plasma membrane into which they insert by crossing it. Membrane domains have been defined for them and also on both sides of the membrane. The one on the external side corresponds to the binding site for messengers that come from other cells, a situation that defines the so-called heteroreceptors. If messengers coming from the cell itself join that site, the so-called autoreceptors are defined.
But chemical receptors can also be located inside cells. They are intracellular receptors and are found in the cytoplasm or in the nucleus. Messages act on them, which due to their chemical nature can cross the plasma membrane, such as steroidal hormones, thyroid hormones and neurosteroids
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