Like what is that step by step explanation
Answer:
the pathway will be under-expressed.
- the alpha subunit helps to bind with either GDP or GTP. when the α subunit is bound with GDP, it will be bound to β and γ subunits and thus forms an inactive state for G-protein.
- when the alpha subunit binds with the GTP, it becomes activated and dissociates β and γ subunits.
if G-protein Coupled Receptor is unable from dissociating β and γ subunits, then the pathway will go under expression.
The chemical qualities of the alpha subunit allow it to bind easily to one of two guanine subunits, GDP or GTP. The protein thus has two functional formations. When GDP is bound to the alpha subunit, the alpha subunit remains bound to the beta-gamma subunit to form an inactive trimeric protein.
G-proteins, cAMP, and Ion Channel Opening. The alpha subunit activates adenylate cyclase, in purple, and loses GTP. Adenylate cyclase converts ATP to cyclic AMP, which then activates Protein Kinase, shown in blue. Protein Kinase phosphorylates an ion channel, letting sodium ions rush into the cell.
As a result of the ligand binding to its site on the G-protein-linked receptor, A) the G-protein changes conformation and GTP replaces the GDP on the alpha subunit. ... Inactivation of the alpha subunit occurs when its own phosphorylase activity removes a phosphate from the GTP.
Answer:
The activity of cyclic AMP phosphodiesterase is prevented by caffeine. The caffeine prevents further dissociation of cAMP, which eventually increases the response within the body. The activity of neurotransmitters, that is, of noradrenaline or epinephrine, gets increased due to enhancement in response.
This further enhances the activity of the heart, the rate of muscle contractions, blood pressure that further helps in delivering more oxygen to the brain, and other parts of the body. Thus, the inhibition of the enzyme cyclic AMP phosphodiesterase helps the athletes to prevent the wall.
Answer:
The goal of materials engineering is to predict and control material properties through an understanding of atomic, molecular, crystalline, and microscopic structures of engineering materials
