Answer and Explanation:
The mechanism of action of statins begins with the inhibition of a protein called HMG-CoA reductase, allowing its substrate to accumulate in the body and promote cholesterol reduction. At that moment, a transporter called OATP (Organic Anion Transporting Polypeptides) takes statins to the epatic tissue where they will be transformed and metabolized until they are eliminated through bile. This elimination is influenced by the P-glycoprotein, which is the main cause of the efflix presented by the bili. This process can get help from other molecules like some protease inhibitors, digoxin and cyclosporine.
The red blood corpuscles have a pigment called hemoglobin that binds to the oxygen and carries it to the whole body in both the conditions, when the body is at rest or when the body is exercising. The oxygenated blood from the heart is carried to the various parts of the body and the de-oxygenated blood from various parts of the body is carried to the lungs where the exchange of gases takes place.
The answer is 4. Hope this helps
