Oncogenes are most like the gas pedal on a car, while tumor suppressor genes are most like the brakes on a car. Oncogenes and tumor suppressor genes are mutated in cancer cells.
Oncogenes are genes overexpressed in cells in which they should not be expressed, thereby leading to cancer.
Some examples of oncogenes are growth factors such as, for example, the Platelet-derived growth factor (PDGF) or Epidermal growth factor (EGF).
Conversely, tumor suppressor genes are genes that act to regulate cell division and replication, thereby their inactivation also leads to cancer.
A well-known example of a tumor suppressor gene is the p53 gene that acts to control cell division and apoptosis (programmed cell death).
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Answer:
A. Both in mitosis and meiosis (II)
B. Mitosis
C. In both
D. Meiosis
E. Mitosis
Explanation:
Prior to every case of cell division in both mitosis and meiosis, the cell always ensures to duplicates its contents including its chromosomes. In both cases of cell division, the sister chromatids separates, apart from in meiosis I where homologous chromosomes separates to opposite poles. Only one cellular division occurs in mitosis which is involved in the growth and development of the diploid individual but in meiosis, two divisions takes place in the gametes (both male and female) to ensure that the haploid number of chromosomes is transfered from both parents each to the offspring ensuring a constant diploid offspring. Thus a diploid parent cell always produces a haploid daughter cell in the gametes during meiosis. In mitosis, the daughter cells are always identical to the parents cells.
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