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Phoenix [80]
3 years ago
12

If cells in the process of dividing are subjected to colchicine, a drug that interferes with the formation of the spindle appara

tus, at which stage will mitosis be arrested (or at which stage will mitosis get stuck and not move on anymore)
Biology
1 answer:
ra1l [238]3 years ago
4 0

Answer:

Colchicine inhibits the formation of microtubules by inhibiting tubulin, a protein required for microtubule synthesis. Microtubules in the form of spindle fibers during cell division pull the DNA from the center of the mother cell into the new daughter cells. If microtubules are not formed DNA will not move into new cells. Hence new cell formation will be inhibited in the metaphase stage. Thus the correct answer is option D.

Explanation:

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2 years ago
increasing intracellular cAMP leads to smooth muscle relaxation by: Group of answer choices inhibiting IP3 channels, leading to
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Explanation

In smooth muscle, cyclic AMP (cAMP) mediates relaxation because cAMP inhibits a specific kinase required for myosin light chain protein (MLCP) phosphorylation, thereby triggering contraction in the smooth muscles. It has been shown that cAMP inhibits 1,4,5-trisphosphate (IP3)-dependent calcium ions (Ca 2+) release by activation of the cGMP-dependent protein kinase (PKG). PKG proteins act to modulate Ca2+ oscillations by stimulating sarcoplasmic Ca2+-ATPase membrane proteins, increasing Ca2+ in the sarcoplasmic reticulum stores and Ca2+ efflux from the cells, and activate voltage-gated potassium (K) channels, thereby leading to membrane hyperpolarization and reducing Ca2+ entry through Ca2+ channels.

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