A nonfunctional CD4 protein on a helper T cell would result in the helper T cell being unable to interact with a class II MHC-antigen complex
Importance of Class II MHC-Antigen complex
- CD4+ T cell-dependent immunological responses need antigen presentation restricted to MHC class II.
Professional antigen-presenting cells (APCs) perform a range of functions that are essential for the generation of an effective and specific immune response.
- Dendritic cells (DCs) investigate their surroundings and gather foreign antigens, such as those derived from bacteria or viruses, before activating CD4+ and CD8+ T cells to initiate adaptive immune responses against these antigens.
- The thymus' DCs and epithelial cells express (and also capture) a diverse set of self-proteins that contribute to both central and peripheral tolerance.
Recognizing the processes involved in the creation (and stability) of peptide-MHC class II complexes in APCs provides crucial information about T cellular metabolism including both normal and pathological settings.
Hence, the correct answer is option D
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# SPJ4
Answer:
See the answer below
Explanation:
Normal height - H
Short height - h
Heterozygous - Hh
A cross involving heterozygotes would be Hh x Hh
Hh x Hh
HH Hh Hh hh
Since H is dominant over h;
HH and Hh would produce normal height phenotypes.
hh will produce a short height phenotype.
Thus;
<em>Probability of normal height phenotype resulting from the cross = 3/4 or 75%</em>
<em>Probability of short height phenotype resulting from the cross = 1/4 or 25%</em>
