Question

Which one of the following is an example of the chemical modification of an active pharmaceutical ingredient? Group of answer choices Converting a crystalline API into an amorphous form Combining a basic API with citric acid to produce the citrate salt of the API Mixing a poorly soluble API with water to produce a suspension Mixing a soluble API with water to produce a solution

Answer 1

Answer: Combining a basic API with citric acid to produce the citrate salt of the API.

Explanation:

Chemical modifications refers to the processes that involve changes in the general composition of drugs to produce another entity with different chemical properties.

From the answer, Basic API combine with citric acid to produce the citrate salt of API which have different chemical properties from the reactants.