Question

You are working for a drug company, trying to modify a protein for use as a drug. There is an alanine in the active site, and you are replacing it with various other amino acids. Choose the amino acid most likely to: Create a bend or kink Choose the answer from the first menu in accordance to the question statement. Add a disulfide cross link Choose the answer from the second menu in accordance to the question statement. Increase interaction with a nonpolar substrate Choose the answer from the third menu in accordance to the question statement. Increase binding to a negatively charged substrate Choose the answer from the fourth menu in accordance to the question statement. Increase binding to a positively charged substrate

Answer 1

Answer:proline, cysteine, Proline

Explanation:Proline causes kinks in the amino acid. Disulfide bonds in proteins are formed between the thiol groups of cysteine residues through the process of oxidative folding. Cys is considered to be hydrophobic, while proline is considered to be polar