Answer:The allosteric inhibitors of integrase (termed ALLINIs) interfere with HIV replication by binding to the viral-encoded integrase (IN) protein. Surprisingly, ALLINIs interfere not with DNA integration but with viral particle assembly late during HIV replication. To investigate the ALLINI inhibitory mechanism, we crystallized full-length HIV-1 IN bound to the ALLINI GSK1264 and determined the structure of the complex at 4.4 Å resolution. The structure shows GSK1264 buried between the IN C-terminal domain (CTD) and the catalytic core domain. In the crystal lattice, the interacting domains are contributed by two different dimers so that IN forms an open polymer mediated by inhibitor-bridged contacts; the N-terminal domains do not participate and are structurally disordered. Engineered amino acid substitutions at the inhibitor interface blocked ALLINI-induced multimerization. HIV escape mutants with reduced sensitivity to ALLINIs commonly altered amino acids at or near the inhibitor-bound interface, and these substitutions also diminished IN multimerization.
Explanation:
Answer:
//variable integer_list to hold a list of integers
DECLARE integer_list
ASSIGN values to integer_list
//variable sum to hold the sum of the elements in the list
DECLARE sum
ASSIGN zero to sum
//loop through the integer_list and sum all it's elements together.
for(int i=0; i<integer_list.size(); i++){
sum += interger_list.get(i)
}
//Show the result of the addition from the for loop
DISPLAY "The sum is " + sum
Explanation:
The above code uses some hypothetical programming language syntax. The second and third lines declare an arbitrary integer list and assign a set of values to it respectively.
The fifth line declares a variable "sum" which will hold the result of summing all the elements in the list. The sixth line initializes "sum" to zero.
The for loop shown iterates through the integer list cumulatively summing its elements.
The result is displayed as written on line 12.
Hope it helps!
<span>When it comes to linear programming, the solution which would be effective in satisfying all constraints in the given program in a simultaneous matter is called that of feasible programming. This is due to the fact that the program can satisfy all requirements at the same time.</span>
This can be used to capture a larger area of acceptably sharp images. This can also be referred to as a deep depth of field, and some cinematographers will simply use the term “depth” to describe shots with a large DOF. It can also be referred to as deep focus.
