By the early 16th century, the Aztecs ruled 500 tiny republics and 5 to 6 million people via conquest and trade. Tenochtitlá/n was Mesoamerica's most populous metropolis with more than 140,000 people. Hence the Aztecs were the biggest civilization in the 16th hundred.

This is further explained below.

<h3>Who are the Aztecs? </h3>

Generally, At the start of the 16th century, the Aztecs had grown to command anything between hundred and four to five hundred teeny-tiny states and between five and six million people.

This was all accomplished under their rule.

In conclusion, this was achieved by either military conquest or commercial exchange. Tenochtitlá/n was the most populated and densely populated civilization ever to be in Mesoamerica.

At the ap/e/x of its power, the city was residence to more than 140,000 people, making it the largest city that has ever existed in Mesoamerica.