Answer: Phagocyte receptors that detect PAMPs
Explanation:
TLRs or Toll-like receptors, are a family of proteins that are part of the innate immune system. TLRs are transmembranous and recognize pathogen-associated molecular patterns (PAMPs), which are groups of chemical characteristics common to certain types of pathogens. Patterns detected by TLRs include lipopolysaccharide, a compound found on the surfaces of Gram-negative bacteria, and double-stranded RNA, which is an integral part of the life cycles of many viruses. These PAMPs are generally important for the survival of the pathogen, so they are well preserved. <u>Activation of these receptors induces inflammatory responses in leukocytes of myeloid lineage, signaling via NF-κB, which is a transcription factor that activates pro-inflammatory genes</u>. Activated TLRs also increase the production of co-stimulatory molecules such as CD80, CD86 and CD40. These proteins, expressed on the surface of antigen-presenting cells, are necessary for the activation of T-lymphocytes by dentritic cells and macrophages already showing antigens in their MHC type II molecules (Major Histocompatibility Complex, they participate in the presentation of antigens to T lymphocytes)
<u>In addition, TLR-mediated signaling on antigen-presenting cells (APCs) plays an important role in linking the innate and adaptive immune responses</u>.
To name one of many:
If Ben's car will not start, then the battery may be dead.
Established of a community in an area of bare Rock or bare sand where no topsoil is present
Answer:Similar to the reaction that occurs in step 1 of glycolysis, a second molecule of ATP provides the phosphate group that is added on to the F6P molecule. The enzyme that catalyzes this reaction is phosphofructokinase (PFK).
