If a phospholipid is located in the outer layer of the bilayer in a vesicle, it will end up in the cytosolic face of the bilayer when the vesicle fuses with the plasma membrane.
The lipids on the exterior of a vesicle will end up in the phospholipid layer on the interior (cytosolic face) of the plasma membrane when it fuses with the membrane. The extracellular fluid in the plasma membrane will be in contact with the lipids on the interior of the vesicle membrane.
What is a phospholipid?
Phospholipids are a subclass of lipids that have two hydrophobic "tails" made of fatty acids connected by an alcohol residue. Their hydrophilic "head" contains a phosphate group (usually a glycerol molecule).
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