Answer:
The cytosolic and mitochondrial pools of CoA are kept separate, and no radioactive CoA from the cytosolic pool enters the mitochondrion.
Explanation:
- Fatty acyl group condensed with CoA in the cytosol are first transferred to carnitine and in this process, CoA is released.
- After this, it is transported into the mitochondrion, where it is again condensed with CoA.
- In this way, the cytosolic and mitochondrial pools of CoA are kept separate, and due to this reason, no radioactive CoA from the cytosolic pool enters the mitochondrion.
- Therefore, according to the given question, the C14 CoA that is added into the liver homogenate along with palmitate shows cytosolic radioactive fraction but not mitochondrial as in the mitochondria a different CoA joins palmitate and not the one containing C14.
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Answer:
In all three cases, the large structure—a train, a sentence, a DNA molecule—is composed of smaller structures that are linked together in non-random sequences— boxcars, letters, and, in the biological case, DNA monomers.
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