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Ket [755]
3 years ago
7

imagine a cell-surface receptor protein is being newly synthesized. How can it get into the membrane that it will ultimately be

a part of? Make a list showing the general steps required for the protein to go from its inception (DNA stage) to its final job site (membrane
Biology
1 answer:
motikmotik3 years ago
8 0

Answer:

the steps for a new receptor synthesis:

Explanation:

Do not forget the steps vary from an eukarityc cell to prokarityc one.  

IN AN EUKARYOTIC CELL:

1- Transcription: in the nucleus, mRNA is synthesized from the DNA sequence that codifies the protein. Exons are spliced if needed by spliceosomes.  

2- From nucleus into cytoplasm: mRNA goes through nuclear membrane into the cytoplasm were ribosomes, substrates for protein synthesis and other organelles are.

3- Ribosomes recognize a signal in mRNA and start reading the genetic code, three consecutive nucleotides at a time and adjust the correspondent tRNAs (tRNAs carry the aminoacids)  

4- Peptide bonds are formed between consecutives aminoacids, and a polypeptide is build up according to the mRNA sequence.

5- (The mRNA has a signal that is recognized by the rough endoplasmic reticulum) The peptide goes into this reticulum (RER) and then into Golgi apparatus. (more chemical modifications are made if needed). By this moment the protein has an inserted portion in a lipid membrane.

6- The protein is transported in a vessel that finally fusions with cytoplasmic membrane and the receptor is in destiny. Hydrophobic aminoacid sequences are inserted in membrane.

IN A PROKARYTIC CELL:

1- Transcription (no splicing is needed, there are not exons)

2- There are not nucleus and cytoplasm divided (no transport)

3- Ribosomes recognize a signal in mRNA and start reading the genetic code, three consecutive nucleotides at a time and adjust the correspondent tRNAs (tRNAs carry the aminoacids)

4- Peptide bonds are formed between consecutives aminoacids, and a polypeptide is build up according to the mRNA sequence.

5- The mRNA has a signal that is guides the growing protein to cellular membrane. Hydrophobic aminoacid sequences are inserted in membrane.

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