Question

In certain cancers, the GTPase activity of the RAS G-protein is inhibited. This means that the RAS protein can no longer hydrolyze GTP into GDP. What effect would this have on downstream cellular events?

Answer 1

Flagging pathway EGFR development      

Explanation:

• The epidermal development factor (EGF) receptor (EGFR) is a receptor tyrosine kinase associated with the guideline of cell development, wound mending, and tissue fix. When EGF ties to the EGFR, a course of downstream occasions makes the cell develop and isolate. In the event that EGFR is actuated at improper occasions, uncontrolled cell development (malignancy) may happen.
• After the ligand ties to the phone surface receptor, the initiation of the receptor's intracellular parts sets off a chain of occasions that is known as a flagging pathway, here and there called a flagging course. In a flagging pathway, second delivery people catalysts and enacted proteins interface with explicit proteins, which are thus initiated in a chain response that in the long run prompts an adjustment in the cell's condition  
• For example, an expansion in digestion or explicit quality articulation. The occasions in the course happen in an arrangement, much like an ebb and flow streams in a waterway. Collaborations that happen before a specific point are characterized as upstream occasions, and occasions after that point are called downstream occasions.