Since we can't see your choices we can only do so much to help you unfortunately. However, the word abiotic means non living. So if it's saying which is NOT an example of an abiotic factor, then your answer would be the choice that has to do with living. For example, plants, animals, etc.
I believe the organelle that is most likely malfunctioning in the patients cells are the lysosomes.
Could u possibly give me any options or is it opionon based. let me know ill answer it in a jiffy:)