They're communities were small in size, due to the fact that they couldn't produce enough food to sustain a larger population.
Disease. When Britain traveled to America, the Natives were hit with Small pox, something they couldn’t handle. The same could happen to other groups of people who do not have the right medical equipment and/or experience.
In addition to patronage, merchant families during the Renaissance began to "spread the ideas" of the Renaissance, but promoting the artwork was that based primarily in Florence outside of the region.
