<span>Lafora disease is the most severe teenage-onset progressive epilepsy, a unique form of glycogenosis with perikaryal accumulation of an abnormal form of glycogen, and a neurodegenerative disorder exhibiting an unusual generalized organellar disintegration. The disease is caused by mutations of the EPM2A gene, which encodes two isoforms of the laforin protein tyrosine phosphatase, having alternate carboxyl termini, one localized in the cytoplasm (endoplasmic reticulum) and the other in the nucleus. To date, all documented disease mutations, including the knockout mouse model deletion, have been in the segment of the protein common to both isoforms. It is therefore not known whether dysfunction of the cytoplasmic, nuclear, or both isoforms leads to the disease. In the present work, we identify six novel mutations, one of which, c.950insT (Q319fs), is the first mutation specific to the cytoplasmic laforin isoform, implicating this isoform in disease pathogenesis. To confirm this mutation's deleterious effect on laforin, we studied the resultant protein's subcellular localization and function and show a drastic reduction in its phosphatase activity, despite maintenance of its location at the endoplasmic reticulum.
I got my information from </span>https://www.ncbi.nlm.nih.gov/pubmed/14722920
I believe it is called lipogenesis.
Answer:
Due to sloppy nature of the field.
Explanation:
This problem of rapidly drainage can be solved if the field should leveled because the portion is rapidly drained due to sloppy nature of the field. Sloppy nature of land moves water at the faster rate from higher elevation to lower elevation. We can see in tillage practices, the farmers used levelers in order to level the field in order to provide even resources such as fertilizers and water. So we can say that this problem can be solved if the field will be leveled.
The Sahel. The Sahel is a region of sub-Saharan Africa and it is also a zone of ecological transition between the Sahara to the north and the wetter savannas to the south. Sahel belt or Sahel is a tropical savanna ecoregion in Africa. Africa is the second largest continent. It has 54 sovereign countries.
<h2>Specialists and Generalists </h2>
Explanation:
Niche is the role played by an organism that how it lives in an environment
Specialists
- Species that have narrow niches are called specialists and this type of niche is called realized niche
- It is narrow because of the presence of ecological barriers and is the space where a species actually lives
Generalists
- Species that have broad niche are called generalists and this type of niche is called fundamental niche
- It is larger than the realized niche due to absence of ecological barriers
- It represents all the environmental conditions where a species is able to live or can live
