Answer:
The answer is reciprocal chromosomal translocation
Explanation:
The Philadelphia chromosome (Ph) is the truncated chromosome 22 generated by the reciprocal translocation t(9;22)(q34;q11) and was first identified in 1960 in a patient with CML [3]. Translocation of the proto-oncogene tyrosine-protein kinase (ABL1) gene located on chromosome 9 to the breakpoint cluster region (BCR) gene located on chromosome 22 results in a BCR-ABL1 fusion gene on the Ph [4, 5]. Three BCR-ABL1 fusion gene hybrids encode BCR-ABL1 protein isoforms p210, p190, and p230, which have persistently enhanced tyrosine kinase (TK) activity. These aberrantly activated kinases disturb downstream signaling pathways, causing enhanced proliferation, differentiation arrest, and resistance to cell death [6, 7]. Tyrosine kinase inhibitors (TKIs) targeting the BCR-ABL1 protein are the most successful targeted therapy for Ph-positive leukemia.
Answer:
Angiosperms are plants with flowers, gymnosperms are plants that do not have flowers. Both groups belong to spermatophytes or seed plants.Gymnosperms are seed-producing plants that do not possess flowers. In gymnosperms, the flowers are replaced by cones, which lack ovaries.
Explanation:
C. the endometrial lining of the uterus
I think it’s D. H2, NaCI, CO
Answer:
Big Bang, the universe is still expanding. Slowly the planets get further away from each other. It's the third planet from the sun, some believed that the earth was in the center of the universe and now we believe the sun is in the middle.Explanation:
