They are formed by mutations. Mutations are random changes. The most common one is a base substitution. One base in the sequence of a gene Is replaced by another.
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Bing, then Google and IMDb
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In 1830, William Lloyd Garrison started an abolitionist paper, The Liberator. In 1832, he helped form the New England Anti-Slavery Society. When the Civil War broke out, he continued to blast the Constitution as a pro-slavery document. When the civil war ended, he, at last, saw the abolition of slavery.