Answer:
The given blank can be filled with decrease in LH and FSH.
Explanation:
Anabolic steroids play an effective function in increasing the performance of an athlete. However, there are certain side-effects, which can exhibit extreme issues on the health of an individual. The use of anabolic steroids results in the supra-physiological concentrations of testosterone and its derivatives.
Via the feedback loop, the generation and discharging of LH and FSH get decreased. The enhanced application of anabolic steroids in comparatively greater concentrations will result in hypogonadotropic hypogonadism, with reduced serum concentrations of testosterone, LH, and FSH.
The statement about physical activity and weight loss and maintenance that is most accurate is, option A. Regular physical activity helps control the percentage of body fat in children and adolescents. Regular physical activity should be maintained by all age groups, but each varies on the optimal amount of activity they need.
Answer:
repeated DNA sequences decrease the target specificity of the CRISPR-Cas system, and may lead to off-target effects
Explanation:
The CRISPR-Cas system is a versatile and powerful tool for gene editing. This gene-editing tool consists of a single guide RNA (sgRNA) that guides the Cas endonuclease protein to the appropriate genomic <em>locus</em>, where Cas generate a double-strand break in the DNA and thus induces DNA repair either by Non-homologous end joining (NHEJ) or Homologous Recombination (HR) repair pathways. The sgRNA consists of a 17-20 nucleotide sequence which is complementary to the target DNA, this sequence is called crispr RNA (crRNA). The existence of repeated DNA sequences hampers the specificity of the CRISPR-Cas tool because a particular sgRNA is able to guide Cas9 to different genomic <em>loci</em> that have the same (repeated) nucleotide sequence complementary to the crRNA. In consequence, repeated DNA sequences may lead to undesired off-target effects, i.e., unintended cleavage (and therefore unintended mutations) at untargeted genomic sites.
Answer:
Transmembrane are inserted into the rough endoplasmic reticulum membrane while they are still in their synthesis stage. They make there way to ER with the help of the signal sequence already present in the synthesizing protein. The signal sequence stops the process of translation and directs the ribosome, carrying the unfinished protein to dock with ER.Translation than restarts when the signal sequence dock with the ER and it occurs in the ER membrane. This process is necessary because it allows the passage of transfer of protein to cross the lipid bilayer, ER lumen facilitate protein folding and it rectifies the aberrant proteins and target them towards cytosol for destruction.