Question

Imagine that you are part of a research team interested in determining the penetrance of a different PRSS1 mutation, Ala16Val. Your team has identified 120 individuals with the PRSS1 Ala16Val allele and found that 48 of the individuals did not display any evidence of pancreatitis.From your data, what is the penetrance of the PRSS1 Ala16Val mutation?

Answer 1

Answer:

60 per cent.

Explanation:

Generally in biological knowledge, people having hereditary pancreatitis disorder have mutations in the PRSS1 gene which result in inflammation of the pancreas possibly causing permanent tissue damage. This disorder is been inherited in an autosomal dominant fashion. Cation trypsinogen in a chain of enzymes made in the pancrease of human here aids food digestion. When found in an encoded situation, it shows more cationic trypsinogen.