For the first question the answer is D
For the second question the answer is B
The answer is d. deletion.
If the DNA sequence is TTCACG, it is expected to be transcribed into AAGUGC.
But, it was transcribed into AAGGC. If we count nucleobases, a transcribed sequence has 5 nucleobases, while DNA sequence has 6 nucleobases. These means that deletion happened.
If insertion occurred, there will be 7 nucleobases in transcribed sequence. In substitution or translocation, the transcribed sequence will be the same size, but with different sequence than the DNA sequence.
Answer:
All the given statements are correct except b.
Antimicrobial resistance (AMR) refers to the ability of a microorganism to grow in the presence of drug or a chemical that would normally limit its growth or kill it.
It makes it difficult for the existing drugs to eliminate the infection as they become less effective against the microbe.
There are five major mechanisms by which a microbe attains resistance against antimicrobial chemical or drug:
- Drug modification or inactivation: A microbial enzyme inactivates the antimicrobial agent. For example, few bacteria produce β-lactamases which provide multi-resistance against β-lactam antibiotics such as penicillin, cephalosporin etc.
- Alteration or modification of target site: An altered target site prevents the antimicrobial agent from binding to its target. For example, alteration of penicillin binding protein (PBP) in Methicillin-resistant <em>Staphylococcus aureus </em>(MRSA).
- Alteration of metabolic pathway: The microbe uses an alternative pathway to circumvent the blocked pathway. For example, sulfonamides-resistant bacteria started using preformed folic acid in place of para-aminobenzoic acid (PABA).
- Decreased drug accumulation: Microbial efflux pumps remove the antimicrobial agent (before it could do any damage) by pumping it out of the cell.
- Decrease in cell permeability: The permeability of the microbial envelope to the antimicrobial agent is decreased
Answer:
Microchimerism is implicated in autoimmune diseases. This phenomenon, called microchimerism, is known as one that can provoke several autoimmune disorders, such as lupus and rheumatoid arthritis.
Explanation:
Chronic disease is a condition of human chimerism that shares similarities with some autoimmune diseases. Chimerism has been known to play a role in the pathogenesis of autoimmune diseases. Chimerism indicates the presence of cells from one individual in another individual. Chimeric cell injection causes lupus-like disease. Regarding all of this we can see that chimerism provokes autoimmune deseases.
