It made it weak. States were gaining more power while the government was losing power. The government was losing control of the states. States were becoming more independent since they started to run individually.
        
                    
             
        
        
        
Answer:
Epidemics (diseases) brought to the Americas by Europeans.
Explanation:
With the discovery of America by Christopher Columbus in 1492, led the beginning of the Columbian Exchange. Europeans started establishing colonies in the New World. Spanish settlers made trading connections with the natives and exchange goods and materials. The European not only traded good but they also brought diseases in the New World,  that led to the decline of the entire civilizations. Majority of the Native American died with coming connecting with smallpox, chickenpox, cholera, malaria, measles, scarlet fever, etc. 
 
        
             
        
        
        
Answer:
Jefferson soon commissioned the Lewis and Clark Expedition, led by Meriwether Lewis and William Clark, to explore the territory acquired in the Louisiana Purchase.
Explanation:
Not sure what you also mean by that , Please give me some more information.