What are the conditions that lead to a "beer gut" due to the excess consumption of alcohol? NADH produced from the metabolism of
ethanol stimulates the citric acid cycle for glucose-derived acetyl CoA. Excess ethanol metabolism leads to an accumulation of NADH that inhibits fatty acid metabolism. The processing of acetate in the liver becomes inefficient leading to a pH imbalance in liver cells, reducing enzyme efficiency in general. NADH inhibits ketone body formation, stimulating glucose rather than fatty acid metabolism. NADH stimulates citric acid cycle enzymes that stimulates glucose-derived acetyl CoA metabolism.
Answer: Excess ethanol metabolism leads to an accumulation of NADH that inhibits fatty acid metabolism.
Explanation:
Fatty acid metabolism is often activated by limited or absence of NADH, however ethanol (the main constituent of most alcoholic drinks) on metabolism yields several molecules of NADH which rather stimulates belly/abdominal fat production often referred to as "beer gut".
