This patient both has left-sided heart failure and right-sided heart failure. In left-sided heart failure, this patient exhibits increasing shortness of breath on exertion as well as three pillow orthopnea which indicates pulmonary congestion. This is because of pooling of blood in the pulmonary circulation. Bipedal edema, in this patient is a grade 2 bipedal edema, reflect right-sided heart failure as there is pooling of blood in the systemic circulation, causing transudation in the most dependent areas of the body.
The affinity of hemoglobin for oxygen is less than its structural analog myoglobin. However, this does not affect hemoglobin's usefulness for the body; on the contrary, it allows hemoglobin to be a more efficient carrier than myoglobin. This is because hemoglobin can release oxygen more easily than can myoglobin. It is both important for oxygen to be carried to different areas and also to be released when needed. The higher affinity of a given protein for oxygen, the harder it will be for that protein to release oxygen when needed. Therefore, hemoglobin's lower affinity for oxygen serves it well because it allows hemoglobin to release oxygen more easily in the body.
Because many living organisms begin in the womb similarly, showing that organisms have a common ancestor
