The drift explanation states that the people with higher socio-economic status (SES) tend to have better lives. It further states that genetics and biology plays an important role in the socio-economic status so that healthier people can enjoy their SES for longer period of time.
Type-II Diabetes, or non insulin-dependent diabetes mellitus (NIDDM) involves a disrupted insulin signaling mechanism [broken]. There is usually a problem with insulin receptors on cells, and not so much the insulin itself (or pancreas). Sometimes the cause of type-II is referred to as "insulin resistance."
We would have a hard time moving and your heart and other major organs would be easier to damage
They must occur in the DNA, which is in each cells nucleus. More specifically the nucleolus of the cell. A mutation occurs in an allele, where a base triplet (or a codon) gets transcribed incorrectly.