Trying to discover the fountain of youth, but ended up in florida :)
Humans!
Recent scientific evidence suggests that during the starving time, the residents of the Jamestown Colony resorted to cannibalism, that is, the eating of dead humans.
Eventually, the growing of tobacco took and Jamestown was able to take hold as a successful colony but during the starving time, Jamestown went from 500 colonists to 60.
Without food people became malnourished therefore a decrease of population due to famine so no births and productivity since people were too weak to work.