Inflammation, your skin, and macrophages are all part of the body's general immune system response to a pathogen. <span>General or non-specific immune response include the cells and mechanisms for defending the host from infection, but those mechanisms are not long-lasting. It includes anatomical barriers (like skin or mucose membranes),recruitment of immune cells to sites of infection, removal of pathogens by white blood cells (like macrophages)…</span>
Mutations can occur in either cell type. If a gene is altered in a germ cell, the mutation is termed a germinal mutation. Because germ cells give rise to gametes, some gamete s will carry the mutation and it will be passed on to the next generation when the individual successfully mates.