Yes, it is true that Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis.
Enhancer of zeste homolog 2 (EZH2), a key histone methyltransferase and EMT inducer, is overexpressed in diverse carcinomas, including breast cancer.
However, the molecular mechanisms of EZH2 dysregulation in cancers are still largely unknown. Here, we discover that EZH2 is asymmetrically dimethylated at R342 (meR342-EZH2) by PRMT1.
meR342-EZH2 was found to inhibit the CDK1-mediated phosphorylation of EZH2 at T345 and T487, thereby attenuating EZH2 ubiquitylation mediated by the E3 ligase TRAF6.
We also demonstrate that meR342-EZH2 resulted in a decrease in EZH2 target gene expression, but an increase in breast cancer cell EMT, invasion and metastasis.
Moreover, we confirm the positive correlations among PRMT1, meR342-EZH2 and EZH2 expression in the breast cancer tissues. Finally, we report that high expression levels of meR342-EZH2 predict a poor clinical outcome in breast cancer patients.
Our findings may provide a novel diagnostic target and promising therapeutic target for breast cancer metastasis.
Learn more about breast cancer here : brainly.com/question/6747562
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DNA, which is a sequence of nucleotides, make up genes. Genes are DNA sequences that code of a functional protein and are controlled by a promoter region on the DNA. DNA, including genes within it, are supercoiled into chromosomes so they are able to fit in the cell. Otherwise, uncoiled DNA in a cell is much longer than the cell itself.
<u><em>Chromosomes</em></u> asserts that our genes set the boundaries within which we can operate
Well, A humans brain is bigger than a Sheeps brain, And a human has more Ridges and Contours also, Hope this helps
The respiratory system is a collection of organs involved in carrying out gas exchange in your body. Deep in the lungs, tiny sacs called alveoli take in oxygen from the atmosphere and release carbon dioxide.
