These things can lead to people feeling those certain feelings
Depression
Anxiety
Stress
Not enough nutrients
Sleep deprived
D. habits and standards that shape how you live is your best answer
Lifestyle is the way you live your life, and the way you live your life is based off of your habits, standards, beliefs, decisions, etc.
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I think the answer is A because of the temperature change on the area
Diagnosis, grade, indirect causes
hope this helps :)