Question

When you decrease the diameter of the stationary phase particles and make them more uniform, in HPLC, which term or terms of the van Deemter Equation is or are minimized?

Answer 1

Answer:

C-term

Explanation:

A correlation between plate height and mobile phase velocity is known as the van Deemter equation.

$H = A + \frac{B}{u}+ C*u$

Where;

H is the plate height

A  is the eddy diffusion term

B is the longitudinal diffusion term

C is the resistance to mass transfer coefficient

u is the linear velocity

Here C-term describes the mass transfer of sample components between the stationary phase and the mobile phase during separation. One of the major factor affecting C-term is the particle size, changing the diameter equally changes the particle size.

The answer is C-term