In the epinephrine pathway, an inhibitor of phosphodiesterase activity would have which of the following effects? A. block the a
ctivation of protein kinase A B. block the activation of G proteins in response to epinephrine binding to its receptor C. prolong the effect of epinephrine by maintaining elevated cAMP levels in the cytoplasm D. block the response of epinephrine
Answer: C). prolong the effect of epinephrine by maintaining elevated cAMP levels in the cytoplasm
Explanation: In the epinephrine pathway, binding of epinephrine to its receptor triggers a conformational change in the receptor and the interaction of the receptor with its associated Gs protein. This interaction causes the replacement of GDP bound to Gs protein with GTP thus activating the Gs protein. The activation of the Gs protein causes the alpha subunit of the Gs protein to dissociate and move to adenylyl cyclase, another membrane protein in the pathway. The association of the alpha subunit of the Gs protein with adenylyl cyclase activates adenylyl cyclase which in turn catalyzes the synthesis of cyclic AMP (cAMP) a second messenger. cAMP is quickly degraded to 5'-AMP by an enzyme phosphodiesterase. Inhibition of the activity of phosphodiesterase will increase the half life and the cytoplasmic level of cAMP thus potentiating the action of epinephrine.
Stomata are the pores found on the surface of leaves and some stems. They are formed from two guard cells (bean-shaped cells) joined at their ends, forming a pore.
The important point is that the surface area to the volume ratio gets smaller as the cell gets larger. Thus, if the cell grows beyond a certain limit, not enough material will be able to cross the membrane fast enough to accommodate the increased cellular volume.
