Question

Why are microdeletions and microinsertions difficult to diagnose using karyotyping?

Answer 1

Answer:

Karyotype is the pictorial representation of all the chromosomes. The karyotype is important to recognize any change in the chromosome structure of an individual.  

The microdeletion and microinsertion is occur at the molecular level. These changes can only be diagnose by the molecular techniques and karyotype only involves the structure of chromosome but not at the molecular level  so cannot diagnose the microinsertion and microdeletion.