Answer:
By designing suitable gene therapies in order to restore target gene expression.
Explanation:
Cystic fibrosis and muscular dystrophy are inherited genetic disorders associated with serious health problems. Cystic fibrosis is caused by mutations in the gene that encodes for the cystic fibrosis transmembrane conductance regulator (CFTR) protein, and it is a condition associated with abnormal production of sticky mucus that leads to problems in the lungs and the digestive systems. On the other hand, muscular dystrophy is produced by mutations in genes localized on the X chromosome such as, for example, the gene 'dystrophin'. Gene therapy is an experimental approach used to compensate abnormal gene function by introducing exogenous genetic material and thus restore their altered protein products. Consequently, personalized gene therapies can be useful to treat inherited disorders such as cystic fibrosis and muscular dystrophy.
<span>I is dominant, i is recessive. The A's and B's are just show which allele I is. When there is just one dominant allele, it masks the recessive in blood typing. Remember IA and IB are codominant.
O is always ii
A is IAi (heterozygous) or IAIA (homozygous)
B is IBi (heterozygous) or IBIB (homozygous)
AB is always IAIB
Remember: You get one allele from each parent!
1. Father must be ii, mother must be ii, so all children must be ii.
2. Father is IAIA (the homozygous one), the mother is IBIB, so the only possibility for the children is IAIB, because you get one allele from the father and one from the mother.
3. Father is IAi, mother is IBi, so the children can be any of the blood types, because they can have all the combinations of genotypes.
4. Father is ii, mother is IAIB. Children can only be IAi or IBi.
5. Father is IAIB, mother is IAIB. Children can be IAIA, IBIB, or IAIB.
Example of Punnett square:
3. Father is type A, heterozygous, mother is type B, heterozygous
Father must be IAi (heterozygous)
Mother must be IBi (heterozygous)
_______IA ____ i
IB____ IBIA____IBi
i _____ IAi______ii
Sorry, that was difficult on here, hope it's understandable.
The father's alleles run across the top, the mother's are on the side, you follow to where they meet to find the possibilities for the children. IBIA (AB blood type), IBi (B), IAi (A), and ii (O) are the possibilities in this case.
Hope that helps!</span>
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