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First pass metabolism of a drug is said to occur when the concentration of a drug that is administered orally is significantly reduced before it reaches the systemic circulation.
First pass metabolism usually occur in the liver.
The routes of drug administration that avoid complete first pass metabolism are: sublingual, transdermal, rectal and inhalation.
Answer:
C. The substance does not directly harm tissues and is not a pathogen, but nevertheless triggers an inflammatory response.
Explanation:
When a person is allergic to a substance, his or her immune system recognizes a harmless substance, such as components in food, pollen, or dust, as a treat. As a consequence, it starts an immune response that leads to inflammation. The substance that starts the allergic reaction is called an allergen, and it is not a pathogen because it is not a real threat to the body since it does not infect cells. When the allergen enters the body, it binds to antibodies that are in contact with a special type of cell. These specific cells will release a substance known as histamine. Histamine will produce an inflammatory reaction affecting different tissues in our body. For example, it can make us sneeze, have a running nose, swelling parts of our body, have itchiness and redness, amongst others.
The answer is: "<span>TATA box" .
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