Cell Theory #1Cells are the basic structure and function of a living thingCell Theory #2All organisms (living things) are made out of cellsCell Theory #3<span>only existing cells can make new cells</span>
Most models can't incorporate all the details of complex natural phenomena. For example, when measuring distances around the Earth it's convenient to model the Earth as a sphere, but this doesn't incorporate variations in distance because of mountain ranges, valleys and other topological features the traveler must traverse. Incorporating these additional details would make the model too complex for easy use. Since models must be simple enough that you can use them to make predictions, they often leave out some of the details.
ALSO.
The conformation of molecules are based on probability. It fails to take into account the electronegativity of individual atoms. And it is ineffective in showing inorganic interactions with metals and such.
Human monoclonal antibody (mAbs) are emerging in the field of cancer therapy and have become an increasing proportion of new drugs that are recently approved. Although there are some methods to obtain antigen-specific mAbs from human B cells, it is generally impossible to directly immunize human beings with antigens of interest. For example, for infectious agents, those approaches are largely restricted. To solve these obstacles, two main approaches have been developed; either by humanizing antigen-specific antibodies from small experimental animals (which is laborious due to the great genetic differences from humans) or rely on the in vitro selection of antigen-specific binders from human antibody repertoires. However, the human mAbs developed by these methods are usually with low affinity.
We are now coming up with a much better idea that is humanizing non-human primates mAbs instead of murine mAbs. Due to the close genetic relationship with humans, immunized NHPs have more potential to be isolated with high affinity antibody to human target than other experimental species, such as mouse, rat and rabbit. In addition, with appropriate method, NHP antibodies are much<span> easier to be humanized</span> without any loss of affinity compared to widely used murine antibodies.
Resource: http://www.creative-biolabs.com/High-Affi-TM-Human-Antibody-Discovery.html
