The TCF transcription factor will bind <u>less</u> frequently with the cell's DNA, resulting in <u>decreasing</u> transcription."less, decreased
Active canonical WNT flagging outcomes in enlistment of β-catenin to DNA by TCF/LEF relatives, prompting transcriptional actuation of TCF target qualities.
The extra translation factors have been recommended to enroll β-catenin and tie it to DNA.
The genome-wide example of β-catenin DNA official in murine intestinal epithelium, WNT -responsive colorectal malignant growth (CRC) cells and HEK293 early stage kidney cells.
The two classes of β-catenin restricting locales.
The top notch speaks to most of the DNA-bound β-catenin and co-limits with <em>TCF4, the noticeable TCF/LEF relative in these cells.</em>
