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serious [3.7K]
3 years ago
10

Let's suppose you were interested in developing drugs to prevent epigenetic changes that may contribute to cancer. What cellular

proteins would be the target of your drugs?
Biology
1 answer:
Vaselesa [24]3 years ago
5 0

Answer:

Potential targets:

1- DNA methyltransferases

2- Chromatin modifiers such as histone acetyltransferases, histone deacetylases, histone methyltransferases, etc.

3- Components of the RNA interference (RNAi) machinery such as Dicer, Argonaute, etc.

Explanation:

Epigenetics can be defined as the study of any heritable change in the phenotype that does not involve modifications in the DNA sequence. Epigenetic mechanisms can be classified into three major types: 1-DNA methylation, 2-histone modifications (e.g., acetylation, methylation, phosphorylation, etc), and 3-regulatory non-coding RNAs (e.g., miRNAs, lncRNAs, siRNAs, etc) that modulate target gene expression via the RNA interference pathway. There are different types of proteins that are involved in these complex epigenetic mechanisms, and those cited above represent only some examples that can be used as therapeutic targets.

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EleoNora [17]

Answer: a body of knowledge

A way of learning about the world

An active science

Explanation:

Your welcome

8 0
3 years ago
One danger of excessive nitrogen levels in water is BLANK.
taurus [48]

Answer:

light

Explanation:

excessive nitrogen can harm water bodies excessive nitrogen can cause overstimulation of growth of aquatic plants and algae excessive growth of the organisms intern can clogged water intakes used to solve oxygen as they decompose and block light to deeper waters

6 0
3 years ago
List ten factors which can be involved in regulating bacterial gene expression (includes specificity and level of expression). "
nirvana33 [79]

Answer:

At least 6 were provided:

1. Transcription.

2. Chromatin domains.

3. mRNA degradation.

4. RNA transport.

5. Translation.

6. Post-transcriptional modification.

Explanation:

Chromatin domains.

Changes to the epigenome can result in changes to the structure of chromatin and changes to the function of the genome.

Transcription.

During transcription, a DNA sequence is read by an RNA polymerase, which produces a complementary, antiparallel RNA strand called a primary transcript.

Post-transcriptional modification.

is a set of biological processes common to most eukaryotic cells by which an RNA primary transcript is chemically altered following transcription from a gene to produce a mature, functional RNA molecule that can then leave the nucleus and perform any of a variety of different functions in the cell.

RNA transport.

mRNA is created during the process of transcription, where the enzyme RNA polymerase converts genes into primary transcript mRNA (also known as pre-mRNA). This pre-mRNA usually still contains introns, regions that will not go on to code for the final amino acid sequence.

Translation.

In translation, messenger RNA (mRNA) is decoded in the ribosome decoding center to produce a specific amino acid chain, or polypeptide.

mRNA degradation.

Different mRNAs within the same cell have distinct lifetimes (stabilities). In bacterial cells, individual mRNAs can survive from seconds to more than an hour. However, the lifetime averages between 1 and 3 minutes, making bacterial mRNA much less stable than eukaryotic mRNA.

3 0
3 years ago
One of the genes affected in Diamond-Blackfan Anemia is called RPS19. This gene plays a role in maturation of the 40S subunit. Y
SCORPION-xisa [38]

Answer:

You tell her that this is incorrect.

Explanation:

The given information is incorrect as both small and large ribosomal subunits are required for protein synthesis. The eukaryotic ribosomes have E, P, and A sites. The A and P sites bind to the aminoacyl tRNA that carry the amino acid encoded by the codon of the mRNA.

The formation of peptide bond occurs between the amino group of amino acid in A site and the carboxyl group of amino acid present on P site. Both 40S and 60S subunit of ribosome contribute the A and P sites.

3 0
3 years ago
What do you call a trait caused by a gene on chromosome 1?
andrew-mc [135]
I'm guessing the answer is a
5 0
4 years ago
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