<span>"It refers to promoting open discussion whenever error occurs without fear of recrimination"
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Answer:
(c) Inherited a mutation in a gene required for mismatch repair
Explanation:
Gene mutations are occasional changes that occur in genes, that is, the procedure by which a gene undergoes a structural change. Mutations involve the addition, deletion or substitution of one or a few nucleotides of the DNA strand. Mutation provides the emergence of new forms of a gene and, consequently, is responsible for gene variability.
It is common for several members of the same family to have the same genetic mutations, as the gene affected by the mutation may condition a trait that DNA cannot repair. An example of this is the family shown in the question above, where several people were diagnosed with the same type of cancer while still young. What probably happened in this family was that people diagnosed with cancer inherited a mutation in a gene needed to repair incompatibility.
The correct answer is the last statement.
If the regulatory serine is mutated to alanine, then acetyl-CoA carboxylase will get activated spontaneously and will produce malonyl-CoA. The increased concentrations of malonyl-CoA will obstruct the oxidation of fatty acids by preventing the entry of fatty acids into the mitochondria.
It is because the AMP-activated protein kinase phosphorylates the serine residues of acetyl-CoA carboxylase to inactivate it. If a mutation occurs in such residues, then the AMPL cannot phosphorylate acetyl-CoA carboxylase and this enzyme will get activated spontaneously.
In such a situation, there will be more than sufficient production of malonyl-CoA, which will inhibit the admittance of more fatty acid getting inside the mitochondria; this will indirectly prevent the oxidation of fatty acids.
<span>In the closed awareness context, patients do not know if they are going to die because the doctor and staff deliberately keep the information from them."</span>
