I think it's 90% but I am not sure.
Answer:
red blood cells (RBCs) misfolding and convert in sickle shapevfrom the donut with out hole shape.
B) The enzyme has active sites where the substrate binds with the enzyme to form a complex. When the substrate binds to the active site, an induced fit is formed where the enzyme changes its shape in order to better serve the substrate and lower the activation energy of the reaction