One hypothesis that explains the result is : A) Two genes are involved with 12:3:1 epistasis, such that A_B_ and A_bb are black, aaB_ is brown,and aabb is green.
Explanation:
- This is a case of Dominant Epistasis.
- When two genes are involved and presence of dominant allele of one gene masks the effect of either allele of the second gene then the epistasis is termed as dominant epistasis.
- In the given case black :brown: green ratio is approximately equal to 12:3:1.
- Here presence of a dominant A allele that is responsible for the black colour masks the effect of either allele of B. Therefore A_B_ and A_bb produces black beetles
- Again , absence of dominant A allows B to express itself and Brown beetles are produced thus aaB_ is brown.
- When both the genes are present as recessive alleles, neither brown nor black colour is expressed and the beetles are green.Thus, aabb are green.
<h2>Calculate the Rf values</h2>
Explanation:
- In the event that an alternate dissolvable were utilized, the Rf worth would not be the equivalent on the grounds that, contingent upon the dissolvable, there is a distinction in dissolvability. On the off chance that an alternate dissolvable was utilized, the general places of the groups would be different.
- The Rf estimation of the xanthophyll is 66% that of carotene since xanthophyll has a H bond with cellulose, which backs it off, and makes it less dissolvable in the dissolvable.
- Carotene is progressively dissolvable in 9:1 oil ether CH3)2CO arrangement, which made it be conveyed higher and have a bigger Rf value.
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Measure the separation the dissolvable voyaged, which is Df, and measure the separation the test arrangement voyaged, which is Ds.
- Ascertain the maintenance factor utilizing this condition <em>RF = Ds/Df. </em>
- Basically isolate the separation the arrangement went by the separation the solvent traveled.
Answer:
Exosomes as Therapeutic Target
Given the fact that elevated exosome levels are often correlated with greater severity of different types of cancer, reducing circulating exosomes to normal levels is one of therapeutic strategies to increase treatment efficacy. There are different approaches to modulate exosome production: 1) Inhibition of exosome formation: inhibit crucial proteins involved in exosome formation pathway; 2) Inhibition of exosome release: inhibit important regulators of exosome release process, increased intracellular Ca2+, change cellular microenvironmental pH; 3) Inhibition of exosome uptake: add proteinase for surface proteins on exosomes may serve as receptors for uptake pathways. In addition to control exosomes production, removal of exosomes from the entire circulatory system might be a novel strategy for cancer treatment.
Exosomes could also be used as cancer immunotherapy becasue tumor-derived exosomes carry antigens that is a great source of specific stimulus for the immune response against tumors. Both tumor-derived and dendritic cell-derived exosomes have showed capability to stimulate tumor antigen-specific responses in experimental animal models and human clinical trials.
Exosomes as Targeted Drug Delivery Vehicles
Exosomes became one of the most common methods applied in drug delivery system because of several advantages they have. Firstly, exosomes normally have a small size 40-100 nm, which is more homogenous compared to other microvesicles. This will lead them to evade rapid clearance by the mononuclear phagocyte and enhances passage through fenestrations in the vessel wall. Secondly, due to their endogenous origin, they are less toxic for and better tolerated by the immune system. It facilitates them to avoid causing side effects that normally occur with synthetic nanoparticles. Additionally, the specific ligand or protein expressed on the exosome surface increases efficiency of cargo into the cytosol of the target cell, and therefore fewer off-target effects. Exosomes are generally found most useful as a drug delivery medium in cancer therapy, anti-inflammation and gene interference therapy such as transferring of miRNA.
There are different kinds of cargos encapsulated by exosomes, especially like siRNA or miRNA. The delivery of RNA is attracting because they are rapid degradation in cell circulation and have the limitation in passing through the membrane and in cellular uptake. Chemotherapeutics loaded into exosomes is also used for cancer therapy such as doxorubicin. In principle, there are four key components to achieve correct functionality and efficacy during exosomes drug delivery:1) Choosing the donor cell type to produce drug-carrying exosomes; 2) Using correspond methods to encapsulate the exosomes cargo; 3) Enhancing the specificity of cargo delivery by targeting peptides on the surface of the exosomes; 4) Administrating exosomes to target the area of disease.
Explanation:
https://www.creative-biostructure.com/exosome-applications-652.htm
I'm pretty sure the answer is B
Answer:
Explanation:
A convergent boundary (also known as a destructive boundary) is an area on Earth where two or more lithospheric plates collide. One plate eventually slides beneath the other, a process known as subduction. The subduction zone can be defined by a plane where many earthquakes occur, called the Wadati–Benioff zone.[1] These collisions happen on scales of millions to tens of millions of years and can lead to volcanism, earthquakes, orogenesis, destruction of lithosphere, and deformation. Convergent boundaries occur between oceanic-oceanic lithosphere, oceanic-continental lithosphere, and continental-continental lithosphere. The geologic features related to convergent boundaries vary depending on crust types.
Plate tectonics is driven by convection cells in the mantle. Convection cells are the result of heat generated by radioactive decay of elements in the mantle escaping to the surface and the return of cool materials from the surface to the mantle.[2] These convection cells bring hot mantle material to the surface along spreading centers creating new crust. As this new crust is pushed away from the spreading center by the formation of newer crust, it cools, thins, and becomes denser. Subduction begins when this dense crust converges with less dense crust. The force of gravity helps drive the subducting slab into the mantle.[3] As the relatively cool subducting slab sinks deeper into the mantle, it is heated, causing hydrous minerals to break down. This releases water into the hotter asthenosphere, which leads to partial melting of asthenosphere and volcanism. Both dehydration and partial melting occurs along the 1,000 °C (1,830 °F) isotherm, generally at depths of 65 to 130 km (40 to 81 mi).[4][5]
Some lithospheric plates consist of both continental and oceanic lithosphere. In some instances, initial convergence with another plate will destroy oceanic lithosphere, leading to convergence of two continental plates. Neither continental plate will subduct. It is likely that the plate may break along the boundary of continental and oceanic crust. Seismic tomography reveals pieces of lithosphere that have broken off during convergence
