They just need to fall asleep
I would go with options C and D
C. Sadness
Explanation:
In this dialogue, Macbeth asks the Doctor in despair if he has any antidote for a mind laden with <u>guilt and sorrow which is the cause of a person's pain not some physical ailment. </u>
This understanding that some mental grief is cause of a physical decay which the doctor will be unable to help him for is evident to Macbeth. Hence the <u>emotion expressed is of sadness and helplessness. </u>
It is obvious that such antidote to cleanse one's mind of sorrows does not exist and Macbeth's insistence on asking for it shows his sadness.
